Formulation and Optimization of Propranolol Bilayer Tablets: A Potential Approach for Effective Management of Hypertension

The purpose of this investigation is to formulate and evaluate the antihypertensive drug propranolol hydrochloride sustained-release bilayer tablets. In formulation, one layer provides a loading dose through immediate release other maintenance for up 12 h controlled release. Different quantities polymers such as Kyron T-314, Hydroxypropyl methylcellulose- K4M, ethyl cellulose were used make bi-layer tablets by direct compression. compatibility study pharmaceutical excipients was conducted Fourier transform infrared spectroscopy studies no interaction found. pre-compression parameter angle repose, bulk density, tapped density compressibility index assessed on produced granules findings good. evaluated post-compression parameters thickness, hardness, friability in vitro studies. dissolution approved out using United States Pharmacopeia apparatus I phosphate buffer pH 1.2 6.8 medium. K4M ethylcellulose combination all formulations but optimized formulation tablet 4 showed higher rate compared follows Higuchi model with non-fickian diffusion based regression coefficient kinetics data cumulative from dosage form.